Simplifying native chemical ligation with an N-acylsulfonamide linker.
نویسندگان
چکیده
We report a simplified procedure for the chemical ligation of peptides by using the sulfamylbutyryl linker as a mildly activating group capable of participating in ligation. When the peptidyl N-methylsulfonamide is directly added with excess thiols to ligation reactions, the speed of reaction is comparable to native chemical ligation.
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ورودعنوان ژورنال:
- Chemical communications
دوره 48 20 شماره
صفحات -
تاریخ انتشار 2012